A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis
نویسندگان
چکیده
منابع مشابه
Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin.
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways correspondin...
متن کاملInterestingness - A Unifying Paradigm - Bipolar Function Composition
Interestingness is an important criterion by which we judge knowledge discovery. But, interestingness has escaped all attempts to capture its intuitive meaning into a concise and comprehensive form. A unifying paradigm is formulated by function composition. We claim that composition is bipolar – i.e. composition of exactly two functions – whose two semantic poles are relevance and unexpectednes...
متن کاملSystems-within-Systems: A Unifying Paradigm
This paper introduces a new paradigm for the design and operation of complex systems. Traditional approaches, including the system-of-systems perspective, attempt to reduce the overall into its fundamental components. Such approaches inherently seek to differentiate, and often isolate, the components. The proposed paradigm seeks a shared mission for all components to exploit recursive design pr...
متن کاملA movement ecology paradigm for unifying organismal movement research.
Movement of individual organisms is fundamental to life, quilting our planet in a rich tapestry of phenomena with diverse implications for ecosystems and humans. Movement research is both plentiful and insightful, and recent methodological advances facilitate obtaining a detailed view of individual movement. Yet, we lack a general unifying paradigm, derived from first principles, which can plac...
متن کاملCharacterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
The biosynthetic gene cluster for the enediyne antitumor antibiotic maduropeptin (MDP) from Actinomadura madurae ATCC 39144 was cloned and sequenced. Cloning of the mdp gene cluster was confirmed by heterologous complementation of enediyne polyketide synthase (PKS) mutants from the C-1027 producer Streptomyces globisporus and the neocarzinostatin producer Streptomyces carzinostaticus using the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2017
ISSN: 1755-4330,1755-4349
DOI: 10.1038/nchem.2829